- Title
- NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients
- Creator
- Malhotra, Sunny; Sorosina, Melissa; Zettl, Uwe K.; Lechner-Scott, Jeannette; Spataro, Nino; Navarro, Arcadi; Comi, Giancarlo; Montalban, Xavier; Martinelli-Boneschi, Filippo; Comabella, Manuel; Río, Jordi; Peroni, Silvia; Midaglia, Luciana; Villar, Luisa M.; Álvarez-Cermeño, Jose C.; Schroeder, Ina; Esposito, Federica; Clarelli, Ferdinando
- Relation
- Multiple Sclerosis Journal Vol. 24, Issue 11, p. 1507-1510
- Publisher Link
- http://dx.doi.org/10.1177/1352458517739137
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2018
- Description
- We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
- Subject
- multiple sclerosis; inflammasome; polymorphisms; interferon-beta
- Identifier
- http://hdl.handle.net/1959.13/1448075
- Identifier
- uon:43306
- Identifier
- ISSN:1352-4585
- Language
- eng
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